You have options in enrichment methods for targeted sequencing. How does Xdrop® compare to other commercial solutions?
On average, other enrichment methods use 10–1000 times more input DNA than Xdrop
From assay design to sequencing results, alternatives to Xdrop take on average 5 times longer
Xdrop stands alone in its use of a completely different strategy to capture target fragments of DNA
Targeted Locus Amplification (TLA)A technique that leverages cross-linking between adjacent sequences to generate complex DNA libraries. The design and implementation is challenging and time-consuming.
CRISPR-Cas9 SystemsUses RNA-guided engineering nucleases to isolate targeted DNA fragments. Requires a large amount of input DNA and achieves moderate enrichment.
Region Specific Extraction (RSE)Target molecules are captures with a large selection of oligos. The right constellation of oligos can be very difficult to optimize.
Xdrop vs. Hybridization Capture – comparable outcomes, complementary uses
Our benchmarking study shows that Xdrop is an agile platform that allows you to easily switch from one target to another and explore each in depth, with a very even coverage, easily spanning across repeats and GC-rich regions. Take a look at our data.
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