March 4, 2021
14:00 GMT / 15:00 CET / 9:00 EST
The ease of new genome editing technologies has opened opportunities to explore in more detail the genetic underpinnings of disease, establish more relevant study models, and develop novel advanced therapies. An essential yet often overlooked aspect of that work is validating edits. Learn from Dr. Tom Cunningham how his team humanizes mouse models to understand the genetics of ALS and let Dr. Peter Mouritzen explain how Xdrop® helps ensure edits are happening how and where intended.
Thomas Cunningham, Senior Investigator Scientist, MRC
Engineering and studying a new generation of knock-in mouse models of motor neuron disease and frontal temporal dementia
Genomic humanisation refers to replacement of entire mouse genes with the human orthologous sequence
Allele QC is critical in order to accurately study the consequences of pathogenic mutations
Dr. Peter Mouritzen, Application Development Services, Samplix, Denmark
Indirect Sequence Capture of any genomic region: the Xdrop™ microfluidics system
Validation of CRISPR edited cell lines detecting unintended kb-long insertions
Identification of integration sites and structural variation in transgenic mice
Reconstruction of complex genomic regions: CYP2D6 gene without confounding effects of pseudogenes.
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