Microfluidics-based solutions delivering high-resolution insights into cells and genomes. Curious? Keep reading.
LONG-RANGE GENOMIC INFORMATIONcapture long fragments of DNA (up to 100 kb)
SMALL INPUT, LARGE OUTPUTgo from ng to µg amounts of DNA
WORK WITH UKNOWN SEQUENCESyou just need to know a short piece within or flanking the target
SINGLE-MOLECULE RESOLUTIONgain an unbiased view of your target’s variation
FUNCTIONAL ANALYSIS IN A SINGLE-CELL FORMATgain an unbiased view of your target cell
RECOVERY OF CELLS Cells can be recovered and expanded for further anlysis
An emulsion forms when two unmixable fluids are forced together. At Samplix, we work with two types of emulsion droplets: single- and double-emulsion droplets. The single-emulsion (SE) droplets have an inner aqueous phase where reagents can be kept in an aqueous buffer surrounded by oil (water-in-oil) (Fig. on the left side). The double-emulsion droplets also have an inner aqueous core, but this core is enclosed by an oil shell inside an outer water buffer (water-in-oil-in water) (Fig. on the right side).
Double-emulsion droplets produced with Xdrop are uniform in size and shape. The droplets display a specific permeability to fluorophores and compounds.
Xdrop and Xdrop Sort produce double-emulsion droplets that act as picoliter-sized reaction chambers or microenvironments for your cells, making it possible to:
Xdrop has proven performance in a range of single-cell format applications, including:
Both Xdrop and Xdrop Sort have proven performance with microbial cells, including
Pictured: Bright field (top) and merged bright field and fluorescent (bottom) images of cellulase-expressing Escherichia coli cell in a double-emulsion droplet (provided by the Schwaneberg Group, RWTH Aachen University)
