The Xdrop technology

Microfluidics-based solutions delivering high-resolution insights into cells and genomes.
Curious? Keep reading.

Droplet formation

 

What makes Xdrop® special?

FOR GENOMIC WORKFLOW

LONG-RANGE GENOMIC INFORMATION
capture long fragments of DNA (up to 100 kb)

SMALL INPUT, LARGE OUTPUT
go from ng to µg amounts of DNA

WORK WITH UKNOWN SEQUENCES
you just need to know a short piece within or flanking the target

SINGLE-MOLECULE RESOLUTION
gain an unbiased view of your target’s variation

FOR CELL WORKFLOW

FUNCTIONAL ANALYSIS IN A SINGLE-CELL FORMAT
gain an unbiased view of your target cell

RECOVERY OF CELLS 
Cells can be recovered and expanded for further anlysis

Droplet properties

Single-emulsion versus double-emulsion droplets

An emulsion forms when two unmixable fluids are forced together. At Samplix, we work with two types of emulsion droplets: single- and double-emulsion droplets. The single-emulsion (SE) droplets have an inner aqueous phase where reagents can be kept in an aqueous buffer surrounded by oil (water-in-oil) (Fig. on the left side). The double-emulsion droplets also have an inner aqueous core, but this core is enclosed by an oil shell inside an outer water buffer (water-in-oil-in water) (Fig. on the right side).  

Variation in inner diameter and permeability

Double-emulsion droplets produced with Xdrop are uniform in size and shape. The droplets display a specific permeability to fluorophores and compounds.

Single emulsion vs Double emulsion

Table DE SE  (1)

How it works - a quick overview

For Genomic workflow

samplix web diagram2

For cell workflow

samplix web diagram2