The Xdrop platform uses microfluidics technology to encapsulate biomolecules in double-emulsion droplets. This approach enables a wide range of single cell functional assays and genomic analyses. Compatible with both flow cytometers and sorters, Xdrop offers a versatile solution for functional and molecular analysis.
The Xdrop and Xdrop Sort are droplet microfluidics instruments capable of compartmentalizing single cells in droplets. Cells can be cultured and assayed within the droplets, retaining any secreted proteins or molecules. Uniquely, our platform enables the analysis and sorting of these droplets on flow cytometer and sorters, making it ideal for cell function assays.
Xdrop technology specializes in double emulsion droplet generation. These droplets are dispersed in an aqueous phase, ensuring compatibility with flow cytometers. This significantly broadens the range of assays achievable, enabling the analysis of secreted antibodies, cytokines, and other proteins, all confined within the droplets. It also facilitates the analysis of cell-cell interactions and cell killing assays, empowering the field of immunotherapy
With single-cell assays in droplets, Xdrop reveals the heterogeneity of CAR T cells. In this study we showed that only about 20% kill their targets within 6 hours, while 33% secrete active granzyme B. Such detailed insights into cellular heterogeneity are not achievable with traditional bulk assays.
Discover the latest Drug Target Review’s eBook entitled “Reveal Cell Function With Single-Cell Resolution” and explore the synergy of microfluidics technology and single cell format flow cytometry for unprecedented insights into immune cell populations’ heterogeneity.
See how our Xdrop DE50 droplets can be used to encapsulate individual immune cells and deliver them for incubation, analysis, and retrieval.
Contact our dedicated support team, which includes field application scientists, cell biologists, and microfludics experts, to discuss your workflow needs. They can help you plan your experiments, from deciding on the best media and fluorophores to discussing downstream analyses.
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