Xdrop microfluidics products prepare even small amounts of DNA for highly targeted sequencing.
Xdrop genomics workflows involve encapsulating long DNA fragments in microfluidics droplets and enriching just the target DNA. This allows highly accurate:
Use Xdrop to prepare your DNA for sequencing.
Localizing lentiviral transduction-inserted CAR cassettes in T cells using Xdrop®.
Starting from just 10 ng of DNA, Xdrop reveals gene cassettes inserted using lentivirus and other transduction systems.
Here, Xdrop reveals 1,000 unique insertion sites of the CAR cassette inserted all over the genome.
Verifying CRISPR editing with Xdrop® enables the detection of unintended off-target rearrangements.
Figure: Depth of coverage of Illumina (blue) and Oxford Nanopore (green) sequencing data (sample ε2/ε2). The main graph focuses on the 100 kb surrounding the detection sequence designed to capture the APOE gene region. The inset zooms in on the central 10 kb surrounding the detection sequence.
Detecting HPV18 integration sites in the human genome using Xdrop®.
Targeted DNA enrichment is often necessary to sequence viral integration sites within complex DNA regions. However, available enrichment methods often fail with high- complexity, unknown, or rearranged regions.
View our published papers.
Transform discovery workflows. Effortlessly encapsulate single-cell libraries, enhancing the speed of your screening campaigns.
Accelerate discovery with high-throughput screening. Encapsulate millions of antibody-secreting cells to uncover rare, high-value variants.
Explore immune cell function in single-cell format assays, including cytokine, granzyme B, and cell killing assays.
