About Us

Discover our vision and connect with us to start a partnership and project.

Our mission

Samplix ApS supports the life sciences and medical research communities with proprietary microfluidics-based solutions designed to deliver the highest-resolution insights into cells and genomes. Samplix technology is designed for encapsulating biological material, including living cells and reactive molecules, for a range of downstream purposes, such as functional analyses of single mammalian cells, assessments of single-cell enzyme activity, and optimization of protein generation. It can also have a role in the characterization of edits in engineered genes via long- or short-read sequencing.

As a leading developer of microfluidics solutions, Samplix stands ready to help academic, corporate and government researchers reach their goals in areas as diverse as engineered cell therapy, molecular engineering, and cell biology.

Our history

How do you get error- and bias-free identification of genomic variants? This was the question that Dr. Marie Just Mikkelsen and Dr. Thomas Kvist wanted to answer in 2012, when they were working on rare genomic variants. At the time, no existing technology could address that important question. Motivated by the challenge, the two scientists set out to develop a method that reveals any genomic variation.

PCR and unintended interactions between DNA molecules during sample handling are often the root of bias and errors in genomic analyses. Marie and Thomas built a team focused on creating a PCR amplification-free workflow with single molecules encapsulated in droplets.

In 2019, after 6 years of product development and thorough testing, the fully developed microfluidics system for droplet-based, PCR-free enrichment of genomic regions was launched under the name Xdrop®.

Since then, Xdrop technology has proven itself in a broad range of applications with human, other animal, plant, and microbial genomes. It also supports the investigation of cell reactions, including enzyme activity and protein synthesis.

With the success of the microfluidics system, Samplix has grown considerably, supporting customers worldwide with their genomics and molecular biology research.

Our management

 

Lars Kongsbak

CEO

Lars Kongsbak provides expertise in building startups, including strategy drafting and establish competent leadership. He has listed two life science companies and is or has been engaged with BlueBee, ViroGates, Exiqon, Novozymes and Novo Nordisk.

Marie Just Mikkelsen

CTO and co-founder

Marie Just Mikkelsen provides expertise in product development, which for Samplix includes instruments, microfluidics technology, molecular biology reagents, and bioinformatics. She has been engaged with Biogasol and Estibio.

Søren Echwald Morgenthaler

VP Intellectual Property Rights

Søren Echwald Morgenthaler provides expertise in patent strategy, freedom to operate analysis and business strategy. He has listed one life sciences company and is or has been engaged with Anapa Biotech, Exiqon and Novo Nordisk.

Peter Mouritzen

VP Application & Market Development

Peter Mouritzen provides expertise in documenting the many applications of the Xdrop technology and builds relationships with key opinion leaders across the globe. He has listed one life science company and has been engaged with QIAGEN and Exiqon.

Our partnerships

Supporting groundbreaking research is integral to our mission. Samplix has established collaborations with leading researchers in genomics and molecular biology. Here are some recent examples.

Bioneer

Samplix and Bioneer collaborate to tackle challenges in genomics.

Bioneer provides customized gene-editing services, including advanced quality control of gene-edited cell models. Through their partnership with Samplix, they will offer their customers access to Xdrop technology.

 Learn more: Bioneer and CRISPR editing verification.

200527 Samplix Bioneer v4

Uppsala University and SciLifeLab

“We have had a long collaboration with the Samplix team. They have listened to our feedback, and we are glad to see how far this technology has come since the early days when we received the world’s first Xdrop in our lab”

- Dr. Adam Ameur, Uppsala University & SciLifeLab

Dr. Adam Ameur from Uppsala University and Science for Life Laboratory (SciLifeLab) has used Xdrop for several projects, including target enrichment and single-molecule sequencing of the TP53 gene for phasing variants in DNA from leukemia patients. With the support of Xdrop, Dr. Ameur and his team successfully phased point mutations present in the leukemia cancer samples.

Photo of Dr. Adam Ameur of Uppsala University and SciLifeLab

Photo credit: Uppsala University

HORIZON 2020

Samplix was awarded a grant from the European Commission’s prestigious Horizon 2020 SME program. From May 1, 2019 to May 1, 2021, this funding helped accelerate the development of Xdrop technology by optimizing the process and products based on user feedback. The grant allowed Samplix to expand our activities and move towards the aim of the grant: Improving DNA analysis for correct healthcare (IMPACT).

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 848497

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What's new for Samplix?

See the latest news about product releases, webinars and events, partnerships and more.

Xdrop DE50 Cartridge(1)

Introducing new technology for mammalian single-cell assays

Xdrop DE50 Cartridge(1)

Achieve single-cell resolution for functional assays of mammalian cells with the newly launched Xdrop DE50 Cartridge. It is designed for encapsulating single living mammalian cells in highly stable double-emulsion droplets. 

This new microfluidics solution has enormous potential for mammalian cell work. It opens up the exciting possibility to transform bulk mammalian cell assays into single-cell assays focused on the potency of engineered cells. What's more, the desired cells can be retrieved for further expansion. We've already performed functional assays on encapsulated cells, such as cytokine secretion and cell killing assays, to prove the utility of this new microfluidics-based approach.

The Xdrop DE50 Cartridge is currently exclusively available through our early access program. Contact us for more information.


Meet Samplix at these events in 2022

Samplix representatives are attending the following conferences and events in 2022. Watch this space for more information on our booth, talks, and other plans.

  • Plant Genomics and Gene Editing Congress: Europe in The Hague in April
  • PEGS Conference & Expo in Boston in May
  • SLAS Europe 2022 in Dublin in May
  • ESHG European Human Genetics Conference in Vienna in June
  • The 10th International Congress on Biocatalysis in Hamburg in August
  • The 6th Applied Synthetic Biology in Europe meeting in Edinburgh in November
  • NextGen Omics in London in November
  • ESGCT Meeting in Edinburgh in November
  • The Long-read Sequencing meeting in Uppsala in November

Looking forward to seeing you there!


International Womens Day 2022

How small companies can #BreakTheBias

The theme for International Women's Day 2022 is #BreakTheBias: whether deliberate or unconscious, the bias against women at a sociopolitical level makes the path to success harder. The organizers of the day are calling on people the world over to try to make a difference by caling out gender bias, discrimination and stereotyping whenever we see it.

Even small companies like Samplix can do something to make a difference and #BreakTheBias. It's vital to take gender bias seriously, and we've tried to do that.

At every level of the company, including senior management, there are women whose ideas help shape strategy and tactics. We all strive to listen to each other's concepts and concerns. Our managers work to empower the brilliant scientists, technicians, application specialists, salespeople, and marketers reporting to them. We interview broadly when advertising new positions and if the demographics of the applicants are limited, we try to ask why. And crucially, we actively try to hire people with different viewpoints so the managers can continuously be challenged on their own ideas.

No organization or individual is perfect in this vital area of equality and inclusion. But it's essential that we all try to create workplaces where everyone thrives without bias. 

International Womens Day 2022


Xdrop Sort News

Introducing Xdrop Sort: the next generation in gene and cell screening

Xdrop Sort News

We are delighted to announce the launch of our new instrument, Xdrop Sort and its microfluidics cartridge, Xdrop DE20 Sort: the next generation in gene and cell screening technology.

Uniquely, Xdrop Sort enables both the encapsulation and sorting of biological material, such as DNA and small cells, within stable double-emulsion droplets.

Together with appropriate sequencing or enzyme analytics technologies, Xdrop Sort is designed for a whole range of high-throughput gene and cell screening applications.

With Xdrop Sort, researchers can more easily reach the highest-resolution insights into the cells and genomes of humans, animals, plants, and microorganisms.

The instrument is currently exclusively available through our early access program: contact us for more information.


Xdrop used in study of underlying cause of genetic disorders

How can we better study genotype–phenotype correlation in genetic disorders and potentially enable more efficient diagnosis? Published in Frontiers in Genetics, this important paper details how to overcome the limitations of traditional methods for the analysis of repeat extensions using microfluidics droplet-based DNA preparation using Xdrop and sequencing using Oxford Nanopore Technologies and Illumina. The study was done by an inter-institutional team including researchers from the University of Verona, the University of Rome Tor Vergata​, the University of Nevada at Reno, GENARTIS and IRCCS.