On this page you will find the following sections:


The instrument manuals describes in details all the steps and materials required to produce or sort droplets.

Please contact us for the latest version of the Xdrop and Xdrop Sort manual. 

Xdrop  version 7.0  December 2023
Xdrop Sort  version 4.0  October 2022

Quick guides

The quick guides summarize the steps for producing and breaking droplets in a handy single-page document.


The recommendations and user-developed protocols (UDPs) give details of workflows developed by Xdrop users.

These workflows may include products not supported by Samplix such as sequencers and flow cytometers. Optimizations may be required.

Software updates

The current software versions are:

Xdrop  version 1.8.7  September 2023
Xdrop Sort  version 1.2  December 2023

For the most up-to-date software versions, reach out to

Technical notes

Screenshot 2023 06 16 at 14.16.08

Encapsulating yeast cells for screening and recovery

Samplix TechNote Improved WGA

Improved whole genome amplification with Xdrop

Samplix TechNote BRCA2 Milestones

Enrichment of long DNA fragments for DeepSeq

Samplix TechNote Benchmarking Xdrop

Benchmarking Xdrop

Service agreement outline(1)


Service agreement outline(1)

Choose a Samplix Service Plan to ensure optimal instrument performance while avoiding the costs associated with unexpected downtime.

Our plans are designed to:

  • Optimize for up-time
  • Enhance your lab’s productivity
  • Ensure critical maintenance requirements aren’t compromised
  • Keep you compliant with regulatory standards

Our comprehensive plans are designed to meet your specific needs, providing dependable, single-source coverage. 

Contact us for more information.


Xtalks & Samplix webinar : Droplet-based WGA: Successfully Sequencing Minute Amounts of Mycobacterium tuberculosis DNA

Discover our latest webinar done in collaboration with Dr. Anzaan Dippenaar from University of Antwerp

By watching this webinar you'll gain insights into:

  • Efficient amplification for WGS: dMDA gives efficient amplification of minute amounts of Mycobacterium tuberculosis DNA, thus enabling precise WGS
  • Precision insights for tuberculosis genomics: dMDA along with Illumina WGS for samples with ≥5-pg DNA provides detailed insights into drug resistance, phylogeny and transmission dynamics in tuberculosis, offering a valuable tool for advancing genomics in infectious diseases

Product videos

Learn more about the process and product in these short videos, then visit our training video collection for more detail on the whole process. 

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Xdrop double-emulsion droplet production

See how straightforward it is to encapsulate your sample (e.g., cells or DNA fragments) in double-emulsion (DE) droplets. In the video, an Xdrop DE50 Cartridge is loaded with natural killer cells and lymphoblasts, which are then encapsulated for a cell-killing assay in single-cell format. Droplets will contain a natural killer cell, a lymphoblast, or both cell types; some will be empty. The droplets with a single cell or no cells act as controls.

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Xdrop Sort double-emulsion droplet sorting

See how straightforward it is to sort your sample (e.g., microbial cells or DNA fragments) when it is encapsulated in double-emulsion (DE) droplets. Pipette the droplets and media into the Xdrop DE20 Sort Cartridge and start your run on Xdrop Sort. In the video, an Xdrop DE20 Sort Cartridge is loaded with droplets containing DNA fragments. Sorting occurs based on fluorescence. You can adjust the detection threshold to ensure you capture all of your precious sample.