Capture the
building blocks of life

See how to encapsulate single molecules,
organelles, or cells for high-resolution analyses.

Achieve single-molecule or single-cell resolution

Ensure that you capture the right material for your single-molecule or single-cell analyses. Our proprietary microfluidics instrument Xdrop supports the highest-resolution genomics, metagenomics, and molecular biology workflows by encapsulating the building blocks of life in picoliter double-emulsion or single-emulsion droplets. This unique approach makes previously unknown genomic regions accessible for long- and short-read sequencing, boosts the resolution of whole genome amplification, supports assessments of single-cell enzyme activity, and more.

Genomics applications

Boost the resolution on your genomics and metagenomics research. Use our proprietary microfluidics instrument Xdrop along with sequencing recommendations and bioinformatics tools to perform a range of genomics workflows. Xdrop has proven performance with long- and short-read sequencing workflows of DNA from humans, other animals, plants, and micro-organisms.

Chromosome CMYK   two rings

Verify CRISPR edits

Characterize and verify edits and avoid PCR bias that can hide unintended rearrangements, e.g., indels.

Chromosome CMYK   two rings(2)

Identify structural variations

Prepare samples for discriminating genes and pseudogenes, identifying gene fusions and inversions, and more.

Long read sequencing two rings CMYK

Enrich for long regions

Capture regions up to 100 kb long with multiplex enrichment that broadens your coverage of the sequence.

long regions bits

Close gaps in sequences

Examine gene clusters and genomic regions with unknown sequences, even from low input amounts.

DNA helix

Perform unbiased WGA

Reduce amplification bias for a demonstrably more uniform and complete coverage of your sample.

long regions with thick bits

Identify viral integrations

Simplify the mapping and resolution of viral insertion patterns when working with viral vectors.

long regions focus

Find transgene integration sites

Prepare samples for easy and unbiased identification of transgene integration sites.

Spotlight: Plant genomics

Overcome the challenges of sequencing the large and complex genomes of plants. Xdrop has proven performance in supporting a full range of plant genomics work, including:

  • Analyses of poorly characterized gene clusters
  • Closure of gaps due to low correspondence between reference genomes and plant varieties
  • Resolution of structural rearrangements in plant genomes
  • Examination of biosynthetic gene clusters

What services does Samplix offer for genomics and metagenomics?

Send your samples to Samplix and our dedicated and experienced services team will deliver the insights you need. We perform all the listed genomics workflows, including standard and custom downstream analytics, in fully equipped laboratories at our Denmark facility.

Cell-based applications

Use our proprietary microfluidics instrument Xdrop to encapsulate single small cells, including microorganisms and algae, together with bioactive molecules. Our highly stable double-emulsion droplets provide a way to incubate individual living cells for assays and sort them to get the highest resolution on cell-based workflows. Xdrop also has proven performance with encapsulating nuclei, with workflows for other organelles being tested.

Accelerating enzyme evolution RGB

Accelerate directed enzyme evolution

Accelerate the directed evolution of intracellular, extracellular and membrane-bound enzymes.

Accelerating pathway evolution RGB

Accelerate pathway engineering

Use a high-throughput, droplet-based workflow to accelerate the identification of efficient cellular pathways.

Screening environmental samples for biocatalysts RGB

Find new biocatalysts in environmental samples

Screen environmental samples for new biocatalysts in high-throughput workflows.

Enzyme activity assessment RGB

Assess enzyme activity at the single-cell level

Use fluorogenic substrates to determine the enzyme activities of single cells in a high-throughput workflow.

Green flourescent protein screening RGB

Perform high-throughput GFP screening

Analyze single cells for gene function with high-throughput green fluorescent protein (GFP) screening.

Flourescent probes used with bacteria RGB

Assess bacterial responses to fluorescent probes

Encapsulate growing bacterial cells with fluorescent probes to determine responses at the single-cell level.

Identifying pathogen inhibiting microorganisms RGB

Identify pathogen-inhibiting microorganisms

Perform high-resolution screening for the microorganisms inhibiting particular pathogens.

Toxonomic species specific isolation RGB

Isolate species from mixed samples

Perform taxonomic species-specific isolation from mixed samples with single-cell resolution.

Functional screening of microbiota RGB

Screen microbiota samples for function

Perform high-throughput functional screening of complex microbiota samples.

New applications

Leverage the versatility of Xdrop to develop your own applications. The highly stable double- or single-emulsion droplets can encapsulate any biological material and are compatible with a broad range of buffers, media, and reagents.

Samplix Services New Applications

What our customers say

“We have had a long collaboration with the Samplix team. They have listened to our feedback, and we are glad to see how far this technology has come since the early days when we received the world’s first Xdrop in our lab.”

- Dr. Adam Ameur, Uppsala University & SciLifeLab

Dr. Adam Ameur, Uppsala University and SciLifeLab

Photo credit: Uppsala University

“We investigate a complex genomic and molecular interaction induced by CRISPR-Cas9 deletion. It requires highly efficient and sensitive target enrichment followed by long-read sequencing. The Samplix Services Team are very knowledgeable and experienced in the specifics of our project. We also received very helpful advice on the data analysis.”

- Keyi Geng, Karolinska Institutet, Sweden

Keyi Geng, Karolinska Instituet, Sweden

“We used Samplix's Xdrop and sequencing services in a project aiming at closing genomic gaps of the herring Y chromosome. We were pleased with the advice we received from Samplix experts regarding experimental design as well as with the speed and quality of the delivered service.”

- Prof. Leif Andersson, Uppsala University, Sweden

Professor Leif Andersson, Uppsala University, Sweden

Photographer: Mikael Wallerstedt

“The services team are very efficient. I have been advised during all steps: from the design of the experiment to optimized methods for high-quality and high-molecular weight DNA extraction from plant tissues. I like the updates I got at each step. I could see the progress of the project and discuss with the team any adjustments that were necessary.”

- Alessandro Tondelli, Council for Agricultural Research and Economics, Italy

Alessandro Tondelli, Council for Agricultural Research and Economics, Italy