See how our unique microfluidics platform boosts the speed and accuracy of functional analyses of mammalian or microbial cells.
What could you achieve if you boosted the speed and accuracy of your functional analyses of living cells? Find out with our proprietary benchtop instrument, Xdrop.
Xdrop encapsulates living cells in highly stable double-emulsion droplets that act as picoliter-sized microenvironments for incubation and downstream analyses.
Xdrop can change how you analyze cells by transforming bulk functional analyses into rapid and accurate assays with single-cell resolution.
Pictured: co-encapsulated lymphoblasts and natural killer cells with staining to show successful immune reaction
Xdrop's double-emulsion droplets act as picoliter-sized reaction chambers or microenvironments for your cells, allowing you to:
Xdrop has proven performance in a range of single-cell resolution functional assays, including:
This shows our unique instrument's potential for engineered cell therapy research, molecular engineering, synthetic biology, and microbial research.
Pictured: Bright field (top) and merged bright field and fluorescent (bottom) images of cellulase-expressing E. coli cell in a double-emulsion droplet (provided by the Schwaneberg Group, RWTH Aachen University)
Xdrop generates two sizes of double-emulsion droplets. The Xdrop DE20 Cartridge generates the smaller droplets, which are ~20 µm in diameter (volume: ~1.5 picoliters) and are suitable for microbial cell workflows. The Xdrop DE50 Cartridge generates the larger size, which are ~50 µm in diameter (volume: ~100 picoliters) and are suitable for mammalian cell workflows.
Pictured: The channels on an Xdrop DE20 Cartridge in which the reagents mix to form ~20-µm diameter droplets
Cells are encapsulated within the droplets in growth medium. Small molecules, such as carbon dioxide and water, can diffuse across the barrier. However, large, complex molecules, such as cytokines and enzymes, remain inside the droplet.
Pictured: The top and underside of an Xdrop DE50 Cartridge in which the reagents mix to form 50-µm diameter droplets
Validating CRISPR edits and CAR-T cassette insertions is an important part of cell therapy research. Xdrop has protocols developed for long- and short-read sequencing of DNA to verify such edits. The workflow involves encapsulating DNA for targeted enrichment in double-emulsion droplets. Downstream sequencing reveals unintended on-target and off-target rearrangements that other methods cannot easily find.
“We have had a long collaboration with the Samplix team. They have listened to our feedback, and we are glad to see how far this technology has come since the early days when we received the world’s first Xdrop in our lab.”
- Dr. Adam Ameur, Uppsala University & SciLifeLab, Sweden
Photo credit: Uppsala University
“We investigate a complex genomic and molecular interaction induced by CRISPR-Cas9 deletion. It requires highly efficient and sensitive target enrichment followed by long-read sequencing. The Samplix team is very knowledgeable and experienced in the specifics of our project. We also received very helpful advice on the data analysis.”
- Keyi Geng, Karolinska Institutet, Sweden
“We worked with Samplix on a project aiming to close genomic gaps of the herring Y chromosome. We were pleased with the advice we received from Samplix experts regarding experimental design as well as with the speed and quality of the results.”
- Prof. Leif Andersson, Uppsala University, Sweden
Photographer: Mikael Wallerstedt
ContactBregnerødvej 963460 BirkerødDenmark
firstname.lastname@example.orgPhone: (+45) 82 30 45 00
CVR 32 30 93 21
Connect with us
Copyright © 2022 Samplix® ApS. All rights reserved. Samplix products and bioinformatics tools are for research use only, not for use in diagnostic procedures.
Web design: www.reklamehuset.dk
Samplix ApS is a biotechnology company. Our website includes information on our proprietary products and their applications in gene and cell screening. It's possible to create a customer account to use bioinformatics tools used for our workflows.