See how to encapsulate single molecules, organelles, or cells for high-resolution analyses.
Ensure that you capture the right material for your single-molecule or single-cell analyses. Our proprietary microfluidics instrument Xdrop supports the highest-resolution genomics, metagenomics, and molecular biology workflows by encapsulating the building blocks of life in picoliter double-emulsion or single-emulsion droplets. This unique approach makes previously unknown genomic regions accessible for long- and short-read sequencing, boosts the resolution of whole genome amplification, supports assessments of single-cell enzyme activity, and more.
Boost the resolution on your genomics and metagenomics research. Use our proprietary microfluidics instrument Xdrop along with sequencing recommendations and bioinformatics tools to perform a range of genomics workflows. Xdrop has proven performance with long- and short-read sequencing workflows of DNA from humans, other animals, plants, and micro-organisms.
Characterize and verify edits and avoid PCR bias that can hide unintended rearrangements, e.g., indels.
Prepare samples for discriminating genes and pseudogenes, identifying gene fusions and inversions, and more.
Capture regions up to 100 kb long with multiplex enrichment that broadens your coverage of the sequence.
Examine gene clusters and genomic regions with unknown sequences, even from low input amounts.
Reduce amplification bias for a demonstrably more uniform and complete coverage of your sample.
Simplify the mapping and resolution of viral insertion patterns when working with viral vectors.
Prepare samples for easy and unbiased identification of transgene integration sites.
Overcome the challenges of sequencing the large and complex genomes of plants. Xdrop has proven performance in supporting a full range of plant genomics work, including:
Send your samples to Samplix and our dedicated and experienced services team will deliver the insights you need. We perform all the listed genomics workflows, including standard and custom downstream analytics, in fully equipped laboratories at our Denmark facility.
Use our proprietary microfluidics instrument Xdrop to encapsulate single small cells, including microorganisms and algae, together with bioactive molecules. Our highly stable double-emulsion droplets provide a way to incubate individual living cells for assays and sort them to get the highest resolution on cell-based workflows. Xdrop also has proven performance with encapsulating nuclei, with workflows for other organelles being tested.
Accelerate the directed evolution of intracellular, extracellular and membrane-bound enzymes.
Use a high-throughput, droplet-based workflow to accelerate the identification of efficient cellular pathways.
Screen environmental samples for new biocatalysts in high-throughput workflows.
Use fluorogenic substrates to determine the enzyme activities of single cells in a high-throughput workflow.
Analyze single cells for gene function with high-throughput green fluorescent protein (GFP) screening.
Encapsulate growing bacterial cells with fluorescent probes to determine responses at the single-cell level.
Perform high-resolution screening for the microorganisms inhibiting particular pathogens.
Perform taxonomic species-specific isolation from mixed samples with single-cell resolution.
Perform high-throughput functional screening of complex microbiota samples.
Leverage the versatility of Xdrop to develop your own applications. The highly stable double- or single-emulsion droplets can encapsulate any biological material and are compatible with a broad range of buffers, media, and reagents.
“We have had a long collaboration with the Samplix team. They have listened to our feedback, and we are glad to see how far this technology has come since the early days when we received the world’s first Xdrop in our lab.”
- Dr. Adam Ameur, Uppsala University & SciLifeLab
Photo credit: Uppsala University
“We investigate a complex genomic and molecular interaction induced by CRISPR-Cas9 deletion. It requires highly efficient and sensitive target enrichment followed by long-read sequencing. The Samplix Services Team are very knowledgeable and experienced in the specifics of our project. We also received very helpful advice on the data analysis.”
- Keyi Geng, Karolinska Institutet, Sweden
“We used Samplix's Xdrop and sequencing services in a project aiming at closing genomic gaps of the herring Y chromosome. We were pleased with the advice we received from Samplix experts regarding experimental design as well as with the speed and quality of the delivered service.”
- Prof. Leif Andersson, Uppsala University, Sweden
Photographer: Mikael Wallerstedt
“The services team are very efficient. I have been advised during all steps: from the design of the experiment to optimized methods for high-quality and high-molecular weight DNA extraction from plant tissues. I like the updates I got at each step. I could see the progress of the project and discuss with the team any adjustments that were necessary.”
- Alessandro Tondelli, Council for Agricultural Research and Economics, Italy