Boost the resolution of genomics and molecular biology workflows

Get Xdrop for single-molecule and single-cell resolution in your assays and sequencing.

Xdrop®

Xdrop is a versatile and user-friendly instrument for preparing DNA, cells and other biological material for high-resolution downstream analyses. It safely and rapidly encapsulates single molecules, DNA fragments, single cells, or single organelles along with assay chemistry in highly stable double-emulsion or single-emulsion droplets. These droplets are stable through PCR, vortexing, incubation, and long-term storage

Together with appropriate droplet sorting, sequencing, and analytics technologies, Xdrop applications include:

  • Long- or short-read sequencing
  • Assessments of gene edits
  • Unbiased whole genome amplification
  • Enzyme activity assessment

With Xdrop, researchers can more easily reach the highest-resolution insights into the cells and genomes of humans, animals, plants, and microorganisms.

We supply the complete range of reagents, cartridges, and accessories required for Xdrop. What’s more, customer support and training is included as part of our standard Xdrop installation service.

Specifications

Width: 25 cm   9.8 inches
Height: 25 cm   9.8 inches
Length: 48 cm   18.9 inches
Weight: 17 kg   37.5 lbs
Voltage requirements:  110-240 V

Xdrop with SE85 Cartridge Unprocessed 2

Why choose Xdrop?

  • Provides the means to prepare genomic material from large libraries for rapid, high-resolution screening
  • Helps answer a range of questions in genomics and molecular biology
  • Supports synthetic biology workflows, such as enzyme evolution and pathway engineering
  • Has a user-friendly interface that makes the power of microfluidics accessible to every lab

Xdrop® Sort

Xdrop Sort uses advanced, proprietary microfluidics technology to cross the next frontier in gene and cell research. It is designed to help researchers reach the highest-resolution insights into the cells and genomes of humans, animals, plants and microorganisms.

This new member of the Xdrop family can both generate and sort double-emulsion droplets in a user-friendly workflow that does not require any experience with fluorescence-based cell sorters.

The workflow starts with capture of 100 kb DNA fragments, small single cells, or other biological material in highly stable droplets for assays like PCR and enzyme activity assessment. Then, based on content fluorescence, droplets are sorted to obtain only the content of interest for high-resolution downstream analyses such as:

  • Verifying CRISPR edits without PCR bias that hides unintended rearrangements
  • Identifying rearrangements like fusions and inversions
  • Closing gaps in genomic regions
  • Identifying viral and transgene integration sites
  • Assessing enzyme activity at the single-cell level
  • Performing high-throughput GFP screening

Xdrop Sort is currently exclusively available through our early access program.

Specifications

Width: 30.5 cm   12 inches
Height: 36.4 cm   14.3 inches
Length: 65.4 cm   25.7 inches
Weight: 23.5 kg   51.8 lbs
Voltage requirements:  110-240 V

Xdrop Sort with people

Why choose Xdrop Sort?

  • Provides the means to screen large and complex gene libraries with unprecedented speed
  • Helps answer a range of questions in genomics and molecular biology, including key questions in gene and cell therapy research
  • Uniquely enables droplet generation and sorting with the same instrument
  • Has a user-friendly interface requiring short training and no previous experience with fluorescence-based sorting

Cartridges and reagents

See the full range of easy-to-use Xdrop Cartridges for encapsulating biological material, including DNA, organelles, and single cells. These proprietary microfluidics cartridges are designed by Samplix for fully self-contained droplet generation on Xdrop and Xdrop Sort. Samplix also provides the full range of reagents needed for the system.

Xdrop® DE20 Cartridge

For encapsulating DNA, RNA, organelles, or small cells

Produce highly stable double-emulsion droplets to encapsulate millions of molecules, organelles, or small cells (up to 6 µm diameter) with the self-contained Xdrop DE20 Cartridge. Each droplet acts as a compartment for single-molecule or single-cell resolution assays. Simply load the reagents and samples, put the cartridge in Xdrop or Xdrop Sort, and run the program.

  • Run 8 samples simultaneously or individually
  • Produce up to 10 million droplets per lane in 45 minutes
  • Ensure a contamination-free workflow

Xdrop DE20 Cartridge for Website

Xdrop SE85 Cartridge for website

Xdrop® SE85 Cartridge

For encapsulating DNA, RNA, organelles, or small cells

Produce single-emulsion droplets to encapsulate millions of molecules, organelles, or cells with the self-contained Xdrop SE85 Cartridge. Each droplet acts as a compartment for single-molecule or single-cell resolution assays. Simply load the reagents and samples, put the cartridge in Xdrop or Xdrop Sort, and run the program.

  • Run 8 samples simultaneously or individually
  • Produce over 50,000 droplets per lane in 40 seconds
  • Ensure a contamination-free workflow

Xdrop® DE20 Sort Cartridge

For sorting double-emulsion droplets containing DNA or small cells

Sort double-emulsion droplets containing fluorescing DNA or small cells with the new Xdrop DE20 Sort Cartridge. Designed for use with our new instrument, Xdrop Sort, this user-friendly system requires no expertise with fluorescence-based sorters. Simply load the reagents and samples, put the cartridge in Xdrop Sort, and run the sorting program.

  • Run up to 8 samples simultaneously 
  • Sort billions of droplets per day
  • Ensure a contamination-free workflow

Xdrop DE20 Sort Cartridge

Reagents image for website

Reagents

For use with Xdrop, Xdrop Sort, and the Xdrop Cartridges

Samplix provides enzymes, buffers, surfactants, positive controls and more, all specifically developed and optimized for use with Xdrop, Xdrop Sort, and the Xdrop Cartridges. This includes reagents for generating droplets and for specific workflows, such as target enrichment. Contact us for more information about our reagents.

Bioinformatics tools

Calculator

Samplix provides upstream bioinformatics tools for primer design, determining input amounts and predicting enrichment. We're soon launching downstream tools for tasks like basecalling of Oxford Nanopore reads and generation of enrichment mapping reports. These tools are provided free of charge to Samplix customers.

Calculate the optimal DNA input range and predict and evaluate the target enrichment using our dedicated calculator set.

Primer design tool

Use the primer design tool to design all the primer pairs for target enrichment using Xdrop: the required number of droplet PCR primers for the detection sequence and qPCR primer pairs for the validation sequence.

Bioinformatics lab
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