Boost the resolution of genomics and molecular biology workflows

Get Xdrop for single-molecule and single-cell resolution in your assays and sequencing.

Xdrop®

Xdrop is a versatile and user-friendly instrument for preparing single cells, including mammalian cells, DNA, and other biological material for high-resolution downstream analyses.

Xdrop boosts the resolution of assays by safely and rapidly encapsulating the target living cells, DNA fragments, or organelles together with the assay chemistry in highly stable double-emulsion droplets. These droplets are stable through pipetting, vortexing, incubation, flow cytometry, sorting, and even long-term storage

Together with appropriate droplet sorting, sequencing, and analytics technologies, Xdrop applications include:

  • Functional assays of single mammalian cells, including cytokine activity and cell-killing assays
  • Cell reaction screening
  • Verification of gene edits
  • Assessment of unintended on- and off-target rearrangments

With Xdrop, researchers can more easily reach the highest-resolution insights into the cells and genomes of humans, animals, plants, and microorganisms.

Xdrop can also generate single-emulsion droplets for other workflows, including to encapsulate DNA for unbiased whole genome amplification. 

We supply the complete range of reagents, cartridges, and accessories required for Xdrop. What’s more, customer support and training is included as part of our standard Xdrop installation service.

Specifications

Width: 25 cm   9.8 inches
Height: 25 cm   9.8 inches
Length: 48 cm   18.9 inches
Weight: 17 kg   37.5 lbs
Voltage requirements:  110-240 V

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Why choose Xdrop or Xdrop Sort?

  • They help answer a range of questions in cell screening and genomics, including key questions in gene and cell therapy research.
  • They support molecular engineering workflows, including enzyme evolution and pathway engineering.
  • They can encapsulate living cells in highly stable double-emulsion droplets for functional assays, incubation, phenotyping, and screening.
  • They have a user-friendly interface and a small footprint to make the power of microfluidics accessible to every molecular biology laboratory.

Xdrop® Sort

Xdrop Sort uses advanced, proprietary microfluidics technology to cross the next frontier in gene and cell research. It is designed to help researchers reach the highest-resolution insights into the cells and genomes of humans, animals, plants and microorganisms.

This new member of the Xdrop family can both generate and sort double-emulsion droplets in a user-friendly workflow that does not require any experience with fluorescence-based cell sorters.

The workflow starts with capture of 100 kb DNA fragments, small single cells, or other biological material in highly stable droplets for assays like PCR and enzyme activity assessment. Then, based on content fluorescence, droplets are sorted to obtain only the content of interest for high-resolution downstream analyses such as:

  • Verifying CRISPR edits without PCR bias that hides unintended rearrangements
  • Identifying rearrangements like fusions and inversions
  • Closing gaps in genomic regions
  • Identifying viral and transgene integration sites
  • Assessing enzyme activity at the single-cell level
  • Performing high-throughput GFP screening

Xdrop Sort is currently exclusively available through our early access program.

Specifications

Width: 30.5 cm   12 inches
Height: 36.4 cm   14.3 inches
Length: 65.4 cm   25.7 inches
Weight: 23.5 kg   51.8 lbs
Voltage requirements:  110-240 V

Xdrop Sort with people

How is Xdrop Sort different from Xdrop?

Both instruments run targeted DNA enrichment workflows  to prepare genomic material from large libraries for screening. They can both also encapsulate living cells for a range of cell-based applications.

Xdrop Sort uniquely enables DNA or cell encapsulation and high-throughput sorting. This enables the screening of large, complex gene libraries with unprecedented speed. 

Cartridges and reagents

See the full range of Xdrop Cartridges for encapsulating biological material, including DNA, organelles, single mammalian cells, and single microbial cells. These proprietary microfluidics cartridges are designed by Samplix for fully self-contained droplet generation on Xdrop and Xdrop Sort. Samplix also provides the full range of reagents needed for the system.

Our newest product is the Xdrop DE50 Cartridge for encapsulating living mammalian cells in highly stable double-emulsion droplets. It is currently exclusively available through our early access program. Get in touch to learn more.

Xdrop DE20 Cartridge for Website

Xdrop® DE20 Cartridge

For encapsulating DNA, RNA, organelles, or small cells

Produce highly stable double-emulsion droplets to encapsulate millions of molecules, organelles, or small cells (up to 6 µm diameter) with the self-contained Xdrop DE20 Cartridge. Each droplet acts as a compartment for single-molecule or single-cell resolution assays. Simply load the reagents and samples, put the cartridge in Xdrop or Xdrop Sort, and run the program.

  • Run 8 samples simultaneously or individually
  • Produce up to 10 million droplets per lane in 45 minutes
  • Ensure a contamination-free workflow

Xdrop® DE50 Cartridge

For encapsulating mammalian cells

Our newest cartridge is designed to produce highly stable double-emulsion droplets to encapsulate mammalian cells, transforming bulk cell assays into single-cell assays. Workflows using the Xdrop DE50 Cartridge include cytokine secretion and cell killing assays. Simply load the reagents and samples, put the cartridge in Xdrop, and run the program.

  • Run 8 samples simultaneously or individually
  • Produce up to 500,000 droplets per lane in 8 minutes
  • Incubate droplets with cells in a CO2 incubator
  • Recover selected cells for expansion

Xdrop DE50 Cartridge(1)

Xdrop SE85 Cartridge for website

Xdrop® SE85 Cartridge

For encapsulating DNA, RNA, organelles, or small cells

Produce single-emulsion droplets to encapsulate millions of molecules, organelles, or cells with the self-contained Xdrop SE85 Cartridge. Each droplet acts as a compartment for single-molecule or single-cell resolution assays. Simply load the reagents and samples, put the cartridge in Xdrop or Xdrop Sort, and run the program.

  • Run 8 samples simultaneously or individually
  • Produce over 50,000 droplets per lane in 40 seconds
  • Ensure a contamination-free workflow

Xdrop® DE20 Sort Cartridge

For sorting double-emulsion droplets containing DNA or small cells

Sort double-emulsion droplets containing fluorescing DNA or small cells with the new Xdrop DE20 Sort Cartridge. Designed for use with our new instrument, Xdrop Sort, this user-friendly system requires no expertise with fluorescence-based sorters. Simply load the reagents and samples, put the cartridge in Xdrop Sort, and run the sorting program.

  • Run up to 8 samples simultaneously 
  • Sort billions of droplets per day
  • Ensure a contamination-free workflow

Xdrop DE20 Sort Cartridge

Bioinformatics tools

Calculator

Samplix provides upstream bioinformatics tools for primer design, determining input amounts and predicting enrichment. We're soon launching downstream tools for tasks like basecalling of Oxford Nanopore reads and generation of enrichment mapping reports. These tools are provided free of charge to Samplix customers.

Calculate the optimal DNA input range and predict and evaluate the target enrichment using our dedicated calculator set.

Primer design tool

Use the primer design tool to design all the primer pairs for target enrichment using Xdrop: the required number of droplet PCR primers for the detection sequence and qPCR primer pairs for the validation sequence.

Bioinformatics lab
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